The tutorial below is designed for use with OpenSim version 4.0 and later.

## I. Objective

Methods for estimating muscle forces from experimental data are an essential part of the biomechanist's simulation toolkit. Static optimization is a widely used tool for estimating muscle activity due to its speed and ease-of-use, and many OpenSim users rely on the Static Optimization Tool as a key part of their simulation research pipelines. Despite its popularity, OpenSim's implementation of this method only permits one type of cost function and a fixed set of constraints, and therefore is only applicable to research questions that can accept these limitations. In this lab, you will write your own code to better understand the elements required to solve the static optimization problem, draw comparisons to OpenSim's implementation, and learn how extend the basic tool to fit new research applications.

By working through this lab, you will:

- Learn the basics of the static optimization problem, including OpenSim's implementation and alternative implementations.
- Become familiar with using the OpenSim API through MATLAB.
- Learn how to write your own static optimization code.

## II. Background

### Problem Definition

The goal of static optimization is to solve for muscle activations that produce the dynamics of an observed motion. Since there are more muscles than degrees-of-freedom in the human body, this problem is "non-unique" (i.e., many possible solutions exist), hence the need for optimization. We often describe this as the "muscle redundancy problem". We use the term "static" since no dynamics appear in the optimization problem: activation dynamics are ignored, tendons are assumed rigid, and multibody dynamics are prescribed via motion data. Most static optimization problems take the following form:

\begin{align*} \text{minimize } \text{ } & \sum_{i=1}^{N_{m}} (a_i)^p \\ \text{subject to } \text{ } & M_j = \sum_{i=1}^{N_m} r_{i,j} * f_i^m & \text{ for } j = 1 \ldots N_q \\ & f_i^m = F_i^{max} (a_i f_l(\tilde{l}_i^m) f_v(\tilde{v}_i^m) + f_p(\tilde{l}_i^m))\cos(\alpha_i) & \text{ for } i = 1 \ldots N_m \\ & 0 \leq a_i \leq 1 & \text{ for } i = 1 \ldots N_m \end{align*} |

where

\begin{align*} a_i & - \text{activation in } i^{\text{th}} \text{ muscle} \\ p & - \text{positive integer} \\ M_j & - \text{net joint moment about } j^{\text{th}} \text{ joint} \\ r_{i,j} & - \text{moment arm for } i^{\text{th}} \text{ muscle about } j^{\text{th}} \text{ joint} \\ f_i^m & - \text{force in } i^{\text{th}} \text{ muscle} \\ F_i^{max} & - \text{max isometric force in } i^{\text{th}} \text{ muscle} \\ \tilde{l}_i^m & - \text{normalized fiber length in } i^{\text{th}} \text{ muscle} \\ \tilde{v}_i^m & - \text{normalized fiber velocity in } i^{\text{th}} \text{ muscle} \\ f_l & - \text{active fiber force-length curve} \\ f_v & - \text{active fiber force-velocity curve} \\ f_p & - \text{passive fiber force-length curve} \\ \alpha_i & - \text{pennation angle in } i^{\text{th}} \text{ muscle} \\ N_m & - \text{number of muscles} \\ N_q & - \text{number of coordinates} \end{align*} |

The labels "minimize" and "subject to" denote the problem cost function and constraints, respectively. The muscle activations are the only problem "design variables", or the values that the optimizer can change to minimize the cost and satisfy the constraints. Net joint moments are typically computed from inverse dynamics, and inverse kinematics is used to compute all muscle kinematic states.

### OpenSim Implementation

OpenSim's Static Optimization Tool is similar to the problem definition above (see How Static Optimization Works). OpenSim uses a similar cost function where activation raised to a user-defined power is minimized. Typically, an activations-squared cost function (p = 2) is used for most research applications. However, OpenSim's implementation does not include passive muscle contributions when computing total muscle force, f^m. Lastly, rather than matching muscle-generated moments to net joint moments from inverse dynamics, OpenSim's StaticOptimizationTool requires that joint accelerations generated from muscle forces match joint accelerations computed from motion data. In this lab, we will use the moment-matching approach, but think about how you would solve the acceleration-matching problem as you work on your code.

### (Optional) Optimization Theory

One important property of static optimization is that the problem is *linear* in its design variables. While the characteristic curves that define muscle forces are non-linear, muscle activations are the only design variables in the problem and appear linearly in the muscle-generated joint moment equations. If possible, it is beneficial to write optimization problems with linear constraints only, as these problems can usually be solved more efficiently than problems with non-linear constraints. Linear constraints are so advantageous that entire subfields in optimization theory are dedicated to solving problems with this form (see Linear Programming and Quadratic Programming to learn more).

## III. Materials

We've provided materials to help you get started writing your own optimization code. You may click on the links provided here, or click the menu icon, , in the top right of the page and "Attachments" to download all files at once. Place all the materials in a common working directory, preferably something not write-protected (e.g., C:\Users\<account_name>\CustomStaticOptimization).

- Files from the Rajagopal model distribution:
**subject_walk_adjusted.osim**– RRA-adjusted Rajagopal2016 model.**grf_walk.mot**– Ground reaction force and torque data.**grf_walk.xml**– ExternalLoads to be added to the model to apply ground reaction loads.**coordinates.mot**– Coordinate values from an inverse kinematics solution.

**loadFilterCropArray.m**– Utility to load STO files into MATLAB array, filter, and crop to a specified time range. This function relies on the osimTableToStruct MATLAB utility that comes with OpenSim.**CustomStaticOptimization.m**– Main assignment file. Write your code here.

If you don't have MATLAB scripting with OpenSim set up already, refer to Scripting with Matlab.

## IV. Coding Static Optimization

In this section, you will code your own version of the static optimization problem described in the Background section. Write your problem in CustomStaticOptimization.m included in the materials. To guide you, we've structured CustomStaticOptimization.m to be completed in individual parts, which are labeled via comments in the starter code (e.g., Part 1). The sections you need to fill in will be denoted with commented brackets like the following:

% TODO { % }

Before you start coding, first look through the whole file and the parts you need to fill in to get a high-level view of the assignment. You may then continue reading through this section for more guidance on the code sections you need to complete.

#### Part 1: Fill in the missing InverseDynamicsTool commands.

To get started, you will need to fill in the missing OpenSim API commands to compute the net joint moments. Refer to the Doxygen page for the InverseDynamicsTool to find the missing commands you'll need.

#### Part 2: Plot and inspect the generalized forces from inverse dynamics.

Before you continue on to the next steps, compare the generalized forces (i.e., the net joint moments, M_j) from inverse dynamics to the plot below to make sure you have computed them correctly. Note that these results are specific to the model and data included with this example.

*Click on this plot to enlarge and download.*

#### Part 3: Remove any unneeded generalized force data columns.

Your static optimization solution should provide a reasonable estimate of muscle activity for walking. Therefore, we should only solve the problem across degrees-of-freedom with reliable experimental measurements that also contribute to the muscle activity solution. Inspect the Rajagopal2016 model included with the lab. Since we're only interested in lower extremity muscle activity, we can exclude matching generalized forces for certain model coordinates from the optimization problem. In addition, you may consider removing some muscle-actuated degrees-of-freedom that may have poor inverse kinematics solutions. Fill in the 'forcesToRemove' array as instructed in the CustomStaticOptimization.m file to remove unnecessary forces.

* Note I: For certain degrees-of-freedom, depending on the motion of interest and muscles included in your model, it will be necessary to include reserve actuators. A reserve actuator serves to contribute towards a given joint moment when the muscles spanning that joint are not able to generate the necessary moment alone. The reserve actuators should also be minimized within the cost function, with a large weighting to prevent their usage. For this lab they are not required*,

*but you may wish to explore including them.*

*Note II: **The inverse dynamics analysis performed in Part 2 had dynamic inconsistencies in the form of residual forces and moments at the pelvis (e.g., pelvis_rotation_moment and pelvis_ty_force). The best practice in this scenario would involve determining the generalized forces for the motion of interest with limited/null residuals, and then perform static optimization to solve the muscle activations - in doing so the muscle activations/forces determined are for a dynamically consistent motion. For this lab it is okay to ignore them and continue with the inverse dynamics results already obtained.*

#### Part 4: Store max isometric force values and disable muscle dynamics

The model provided for you includes 80 lower-extremity Millard2012EquilibriumMuscles. We need to store an array of max isometric force values so we can compute total muscle force in the optimization. We will also disable activation and tendon compliance dynamics in each muscle, since static optimization does not include muscle dynamics. An example of how to disable activation dynamics for a given muscle is below:

muscle.set_ignore_activation_dynamics(true);

For a list of the available API commands for the muscles to complete these tasks, see the Millard2012EquilibriumMuscle API docs.

#### Part 5: Perform static optimization.

Use FMINCON, MATLAB's constrained optimization solver, to solve the static optimization problem with an activations-squared cost function (i.e., \sum_{i=1}^{N_{M}} (a_i)^2). This is the main part of the coding assignment and will likely take the most time to complete. There is some starter code to select which data points to solve the problem on and to construct the FMINCON options structure; the rest is up to you!

Some things to consider:

- Try outlining your problem in pseudocode before writing any actual MATLAB code.
- Which elements of the problem are the same across all time steps and which elements need to be computed at each time step?
- Similarly, which computations need to happen "inside" the optimization, and which can be pre-computed?
- How will you implement the problem cost function? The first argument to FMINCON accepts a MATLAB function handle, which is a MATLAB variable type that represents a function. Function handles can be the typical named functions or anonymous functions. Note that the function handle passed to FMINCON can only be a function of the problem design variables.
- How will you implement the problem constraints? Consider the discussion from the Background section.

#### Part 6: Plot results.

Plot your muscle activation solution and any other relevant outputs.

## V. Follow-up Questions

- Describe the muscle activation solution you plotted in Part 6. Does your solution match muscle activity levels for normal walking? Compare your solution to electromyography (EMG) data from the literature. What are potential explanations for any discrepancies?
- Provide 3 research questions that you could use your new static optimization code to answer. For each question, briefly describe any additions or changes to the data, model or code necessary.
- Reflection questions.
- Approximately how long did it take you to complete this assignment?
- Was the assignment too hard/too easy?
- Do you think the skills learned were mostly worth the time invested in this assignment?
- If you could make one improvement to this assignment for future classes, what would it be?